Renal Pharmacoepidemiology & Adrenergic drugs

Chronic kidney disease (CKD) is a type of  progressive loss in kidney function over a period of months or years.  Early on there are typically no symptoms Later, leg swelling, feeling tired, vomiting, loss of appetite, or confusion may develop.Complications may include heart disease, high blood pressure, bone disease, or anemia. A great no of  patients enrolled in the end-stage renal disease (ESRD). Although the exact reasons for the growth of the ESRD is unknown, changes in the demographics of the population, differences in disease burden among racial groups, and under-recognition of earlier stages of CKD and of risk factors for CKD may partially explain this growth .However, despite the magnitude of the resources committed to the treatment of ESRD and the substantial improvements in the quality of dialysis therapy, these patients continue to experience significant mortality and morbidity and a reduced quality of life.

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